liquidbiopsyinfo.com - LIQOMICS Liquid Biopsy Knowledge Base The LIQOMICS Liquid Biopsy Knowledge Base

liquidbiopsyinfo.com

The LIQOMICS Liquid Biopsy Knowledge Base

Comprehensive, evidence-based information on liquid biopsy applications for minimal residual disease (MRD) detection and molecular profiling across 25 cancer types. Curated from peer-reviewed literature and clinical trial data to support informed clinical decision-making.

Closing the Information Gap, Together

Liquid biopsy — the analysis of tumor DNA from a simple blood draw — is transforming cancer diagnostics. The scientific evidence is growing at an extraordinary pace: new studies, new indications, new clinical data — published almost daily.

But here lies the problem.

If you are an oncologist trying to determine whether MRD testing could guide treatment decisions for a specific patient — where do you turn? If you are a patient who has heard about liquid biopsy and wants to understand what the evidence says for your type of cancer — how do you find reliable, current answers?

Today, this information is scattered across hundreds of publications, conference abstracts, and clinical trial databases. No single resource pulls it together in a way that is accessible, structured, and up to date. This is the gap we set out to close.

Who we are

We are LIQOMICS — a European pioneer in the detection of circulating tumor DNA (ctDNA). For years, our work has focused on making liquid biopsy diagnostics available to every patient who can benefit from them. But access to testing alone is not enough. Patients and oncologists also need access to the evidence that supports informed, confident decisions.

That is why we created liquidbiopsyinfo.com.

What this platform offers

liquidbiopsyinfo.com provides structured, evidence-based information on liquid biopsy applications — covering minimal residual disease (MRD) detection and molecular profiling across more than 20 cancer types. The content is grounded in peer-reviewed literature and clinical trial data, organized to help you quickly find what is relevant to your specific situation.

A word on how we work — and our limits

We believe in transparency. The volume of data in this field is vast and growing fast. To keep this resource current, we use AI to structure, synthesize, and update the information presented here. This allows us to move at the speed the science demands — but it also means we must be honest about the boundaries.

The information on liquidbiopsyinfo.com is for educational purposes only and should not be used as a basis for medical decisions. Always consult qualified healthcare professionals for clinical advice and treatment planning.

We know that AI-curated content requires human oversight to meet the standards that patients and clinicians deserve. That is why we are committed to building a continuous review process — and why we are actively seeking collaboration with clinical experts, researchers, and medical professionals who share our goal of making this resource as accurate and trustworthy as possible.

An invitation

We see ourselves not as an authority handing down information, but as an ally — working alongside oncologists and patients to make sense of a rapidly evolving field. We move fast because the need is urgent. We are transparent because trust must be earned. And we are reaching out because the best outcomes come from collaboration.

If you are a clinician, researcher, or expert in liquid biopsy diagnostics and would like to contribute to our review process, we would welcome the conversation.

Contact us →

— The LIQOMICS Team

Liqomics Testing Solutions

Lymphoma Testing

LymphoVista

Specialized liquid biopsy solutions for lymphoma minimal residual disease monitoring and molecular profiling. Covering Hodgkin Lymphoma, DLBCL, and Follicular Lymphoma with high-sensitivity ctDNA detection optimized for hematologic malignancies.

Learn More →

Solid Tumors

CancerVista

Comprehensive ctDNA testing platform for solid tumors including MRD detection, treatment response monitoring, and actionable mutation profiling. Supporting precision medicine approaches across 20+ solid tumor types with validated clinical performance.

Learn More →

Disclaimer:

This content was compiled with AI assistance and is for educational and informational purposes only. The information presented here should not replace professional medical advice. Always consult with qualified healthcare providers for medical advice and treatment decisions.

Evidence-Based Rankings: Top ctDNA Applications

Ranked by strength of clinical evidence, trial outcomes, and validation across independent studies

Understanding Evidence Badges:

  • Level 1 RCT = Randomized Controlled Trial with clinical outcomes (highest level of evidence)
  • NCCN Guidelines = Included in National Comprehensive Cancer Network clinical practice guidelines
  • HR X.X = Hazard Ratio for recurrence, progression, or survival (higher values indicate stronger prognostic power)
  • Prospective = Data from prospective clinical trials (forward-looking studies)
  • Validation = Findings confirmed across multiple independent studies

Top MRD Detection Applications

Strongest Evidence for Minimal Residual Disease Monitoring

1

Bladder Cancer (MIBC)Level 1 RCT

IMvigor011 (NEJM 2025): First RCT proving ctDNA-guided immunotherapy improves DFS and OS. Exceptional HR >10 for recurrence risk.

2

Colorectal CancerLevel 1 RCT

DYNAMIC trial: ctDNA-guided therapy safely reduces unnecessary chemotherapy while maintaining excellent outcomes. HR 11.99 for recurrence.

3

Anal CancerHR 5.1

ACT II trial: Post-treatment ctDNA positivity HR 5.1 (95% CI 2.4-10.8, p<0.001) for progression. HPV DNA detection 98%. Excellent prognostic marker.

4

Laryngeal Cancer (HNSCC)HR 27.4

MAESTRO study: HR 27.4 for event-free survival (p<0.0001), HR 8.3 for OS. Lead time 7.0 months. NPV 91.7%. Multiple validation studies.

5

DLBCLNCCN Guidelines

Now in NCCN 2.2025 guidelines. HR 13.69 for end-of-treatment MRD. PFS 85% vs 15% (MRD- vs MRD+).

6

Endometrial CancerHR 6.2-25.4

Exceptional prognostic range. Recurrence: 52-58% (ctDNA+) vs 0-6% (ctDNA-). Lead time 3.1 months. RAINBO trials ongoing to validate predictive utility.

7

Cervical CancerHR 5.50-7.78

HPV ctDNA at 3 months post-treatment: HR 5.50-7.78 for recurrence. Lead time 164 days (5.6 months). 100% specificity. NPV 95%.

8

Lung Cancer (NSCLC)Multiple trials

Meta-analysis of 30 studies: HR 11.19 for PFS, 6.34 for OS. Median lead time 5.5 months. Validated across large cohorts.

Top Genotyping Applications

Strongest Evidence for Actionable Mutation Detection

1

Lung Cancer (NSCLC)NCCN 2024

ctDNA equivalent to tissue for complete genotyping. EGFR, ALK, ROS1, BRAF, MET, RET, NTRK, KRAS G12C. 95% success rate.

2

Colorectal CancerFDA-approved uses

RAS, BRAF, HER2, MSI-H detection guide therapy selection. Multiple FDA-approved therapies based on ctDNA results.

3

Breast CancerClinical utility proven

ESR1 mutations (30-40%): PADA-1 showed treatment switching benefit. PIK3CA: Alpelisib FDA-approved.

4

Biliary Tract CancerExceptional survival

FGFR2 fusions: Futibatinib OS 123 vs 37 months. IDH1: Ivosidenib approved. 44% of patients have targetable alterations.

5

MelanomaBRAF V600E/K

~50% prevalence. Multiple approved targeted therapies (dabrafenib/trametinib). Treatment response monitoring validated.

6

Prostate CancerBRCA1/2/ATM

~20% mCRPC harbor HRR mutations. Olaparib FDA-approved. PROfound: PFS 7.4 vs 3.6 months for BRCA1/2.

7

Pancreatic CancerKRAS, BRCA1/2

KRAS >90% prevalence. BRCA1/2 germline 4-7%: Olaparib approved (POLO: PFS 7.4 vs 3.8 months).

8

Liver Cancer (HCC)Predictive

TERT promoter (51-61.5%): Predicts atezolizumab-bevacizumab response. Important for treatment selection.

Cancer-Specific Evidence Summaries

Comprehensive reviews of ctDNA testing applications across more than 20 cancers

Colorectal Cancer

Level 1 RCT evidence (DYNAMIC). HR 11.99. GALAXY study n=2,240. Lead time 4.8 months.

Lung Cancer (NSCLC)

NCCN 2024: ctDNA equivalent to tissue. Meta-analysis HR 11.19. 9+ actionable targets.

Breast Cancer

PADA-1 interventional trial. ESR1, PIK3CA validated. T-DXd approval based on ctDNA data.

Bladder Cancer (MIBC)

BREAKTHROUGH: IMvigor011 (NEJM 2025) first RCT proving ctDNA-guided therapy improves DFS/OS.

Pancreatic Cancer

KRAS >90%. BRCA1/2: Olaparib approved. Early detection ~2 months before imaging.

Gastric Cancer

HR 6-8 for recurrence. HER2 amplification ~20%. Lead time 3-4 months.

Esophageal Cancer

Neoadjuvant response prediction. HR ~8 for MRD positivity. HER2, PD-L1 detectable.

Prostate Cancer

BRCA1/2/ATM ~20% mCRPC. PARP inhibitors approved. AR variants guide resistance.

Liver Cancer (HCC)

TERT promoter 51-61%. Predicts atezolizumab response. Surveillance for recurrence.

Kidney Cancer (RCC)

Low shedder: 33% detection. VHL, PBRM1, BAP1 mutations. Angiogenesis pathway genes.

Endometrial Cancer

STRONGEST BIOMARKER: HR 15.5. Recurrence 52-58% vs 0-6%. MMRd/MSI-H ~30%.

Cervical Cancer

CALLA: HR 0.04 (96% risk reduction). Lead time 164 days. Nearly 100% HPV DNA detectable.

Ovarian Cancer

HR 5.3-6.7 for PFS. Lead time 5.9-10 months. 93-100% baseline detection. MRD-: 24-28 months vs MRD+: 6-7 months PFS.

Hodgkin Lymphoma

High detection: 92-97% baseline sensitivity. MRD-: 88% vs 25% PFS. CD30 nearly universal.

DLBCL

NOW IN NCCN 2.2025. HR 13.69. PFS 85% vs 15%. GCB vs ABC classification.

Follicular Lymphoma

GALLIUM, SWOG trials. Epcoritamab + R2 approved Nov 2025: 79% risk reduction.

Anal Cancer

HR 28.0 for DFS. Sensitivity 82-100%. HPV DNA detection 98%. Chemoradiation response.

Biliary Tract Cancer

FGFR2: OS 123 vs 37 months. IDH1 mutations. 44% targetable. Erdafitinib, ivosidenib approved.

Glioblastoma

CSF superior to plasma. EGFRvIII, TERT, IDH1. Detection rates 40-87% depending on method.

Laryngeal Cancer

HPV+ vs HPV-. ctDNA clearance predicts response. Lead time 2-4 months. Chemoradiation monitoring.

Oral Cavity & Throat Cancer

HPV status critical. MRD detection HR ~8. TP53 most common. Treatment response monitoring.

Sarcoma

Heterogeneous group. Fusion oncogenes detectable. Limited data but emerging promise.

Testicular Cancer

miR-371a-3p superior biomarker (90-92% sensitivity). ctDNA emerging. Resistance monitoring.

Thyroid Cancer

SEVERE LIMITATION: Only 25% detectable. RET fusions: Selpercatinib standard of care.

Melanoma

BRAF V600E/K ~50%. HR 2.9-7.9 for recurrence. Lead time 3-4 months. Resistance tracking.